Mayo Greenberg has been in charge of the laboratory up to his retirement in 1992 after which Ewine van Dishoeck has been formally leading the laboratory until 2004. In this period much of the daily work was taken care of by Willem Schutte and Pascale Ehrenfreund. Stephan Schlemmer (now Cologne) has been heading the group for a short period after 2004. Since 2005 Harold Linnartz is in charge of the Raymond and Beverly Sackler Laboratory for Astrophysics. Under his supervision the laboratory has been expanding. With eight specialized setups, research is nowadays performed with a focus on transient species of astrophysical interest as well as the spectroscopy of interstellar ices and fundamental properties of atom and photon induced processes in interstellar ice analogues. More recently also the photodynamics of PAHs are studied. The laboratory has moved into the center of a number of large astrochemistry networks, specifically within NOVA, the Netherlands Research School for Astronomy, LASSIE and EUROPAH, two large European FP7/H2020 projects, DAN, the Dutch Astrochemistry Network, and PEPSci, a network to study Planetary and ExoPlanetary Science. In 2009 Prof. Linnartz was awarded a 1.5 MEuro VICI grant to further 'Unlock the Chemistry of the Heavens'. The laboratory benefits much from scientific collaborations with other astrochemists - particularly the inhouse colleagues Profs. Tielens and van Dishoeck - who are very actively supporting ongoing research.
Since its start in 1975, more than 30 PhD theses were completed in the Sackler Laboratory. With roughly 500 scientific publications the laboratory has substantially contributed to the understanding of the physics and chemistry of inter- and circumstellar processes. Currently it is one of the largest laboratories in astrophysics embedded in an academic observatory.
In 2014 the astrobiology lab group of Prof. Ehrenfreund has joined the group. This now allows to perform research at the border lines of chemistry and biology, ultimately with the aim to answer the question how life came to Earth.